These peer-reviewed proceedings document the broad impacts and value of collaboration between university researchers in Canada and the South, as discussed at the June 2005 colloquium organized by the Association of Universities and Colleges of Canada. They capture the richness of the 12 presentations that profiled Canadian researchers working in partnership with colleagues in developing countries. The colloquium provided an academic forum for university researchers around the world to engage with their peers and relevant stakeholders in a meaningful discussion on the impacts of North-South research partnerships.